EDTA-CaNa2 (CAS 62-33-9): Complete Buyer's Guide

Written by: ALEN, Chemical Engineer, MOSINTER | 15 years in vitamin manufacturing and pharmaceutical APIs
 

Three procurement managers reached out to me last month with the same frustration: they'd been sourcing EDTA-CaNa2 (CAS 62-33-9) from different suppliers, but batch-to-batch inconsistency was causing formulation failures. One mentioned that his team had rejected two consecutive shipments due to off-spec moisture content. Sound familiar?

EDTA Calcium Disodium Salt (ethylenediaminetetraacetic acid calcium disodium salt) is a white, odorless crystalline powder that functions as a highly effective chelating agent. With the molecular formula C10H12CaN2Na2O8, this compound binds metal ions like iron, copper, lead, and mercury, preventing oxidation, discoloration, and off-flavors in food, cosmetic, and pharmaceutical applications.

This guide covers everything you need to make an informed purchasing decision - from technical specifications to supplier evaluation criteria that most buyers overlook.

In This Article

What Is EDTA-CaNa2 and Why Does CAS 62-33-9 Matter?

Key Applications Across Industries

Technical Specifications That Affect Performance

How to Evaluate Supplier Quality

Regulatory Compliance and Safety

FAQ

1. What Is EDTA-CaNa2 and Why Does CAS 62-33-9 Matter?

If you've ever wondered why some suppliers reference "CAS 62-33-9" while others just say "calcium EDTA," here's the distinction that matters for your procurement process.

The CAS Registry Number (62-33-9) is the unique, internationally recognized identifier for EDTA Calcium Disodium Salt. According to PubChem, this identifier ensures you're getting the exact chemical compound - not a similar-sounding variant like disodium EDTA (CAS 139-33-3), which has different properties and regulatory approvals.

What most suppliers won't tell you: the calcium in EDTA-CaNa2 isn't just a naming convention - it's functionally critical. Because the calcium is already chelated, this form selectively binds only metals with higher EDTA affinity (like lead, copper, and iron) while releasing the calcium. This selectivity makes it safer for pharmaceutical applications where calcium depletion would be dangerous.

Technical Properties

2. Key Applications Across Industries

A cosmetics formulator in Germany recently asked me why her cream was turning brown after three months on the shelf. The answer came down to trace copper ions in her water source reacting with the formulation. EDTA-CaNa2 would have prevented this entirely by sequestering those metal ions before they could catalyze oxidation.

 

Food Industry (E385)

In the EU, calcium disodium EDTA carries the food additive designation E385. The U.S. FDA (21 CFR 172.120) permits its use in specific foods at defined concentrations. Key applications include:

Canned vegetables: Prevents discoloration in legumes, mushrooms (up to 365 ppm)

Mayonnaise and salad dressings: Preserves freshness, prevents rancidity (75-100 ppm)

Carbonated beverages: Maintains flavor, reduces turbidity

Canned seafood: Prevents struvite crystal formation in shrimp (250 ppm)

Pharmaceutical Applications

EDTA-CaNa2 is FDA-approved for treating heavy metal poisoning, particularly lead toxicity. Unlike disodium EDTA, the calcium form doesn't deplete the body's calcium stores, making it significantly safer for systemic use. It's marketed under names like Calcium Disodium Versenate in clinical settings.

Cosmetics and Personal Care

In lotions, face creams, and soaps, EDTA-CaNa2 acts as a chelating agent that enhances product stability and extends shelf life. By binding trace metals from water and other ingredients, it prevents oxidative degradation of active compounds and maintains consistent product performance.

3. Technical Specifications That Affect Performance

Here's what I've learned from 15 years of working with chelating agents: the Certificate of Analysis (CoA) numbers that procurement teams typically focus on - purity and heavy metals - aren't always the most critical for your application.

The FDA requires a minimum 99% purity for food-grade calcium disodium EDTA (either dihydrate or trihydrate form). However, for pharmaceutical applications, you'll want to verify USP or EP compliance, which includes additional testing for microbial limits and specific impurities.
 

Parameters Worth Negotiating

Moisture content is the silent killer of batch consistency. The dihydrate and trihydrate forms have different water content, which affects dissolution rate and effective concentration. If your formulation is sensitive to water activity, specify which hydrate form you need and set a tighter moisture specification than the standard.

4. How to Evaluate Supplier Quality

After reviewing over 200 supplier audits in my career, I've noticed a pattern: the questions most buyers don't ask are often the ones that matter most.

Beyond certifications, ask suppliers about their batch testing frequency, raw material sourcing, and whether they can provide stability data. A supplier who manufactures in-house will typically offer better consistency than a trader who sources from multiple factories.

Red Flags to Watch For

CoA dates that don't match production batch dates

Reluctance to provide retain samples

Pricing that's significantly below market average (often indicates quality shortcuts)

No clear answer about manufacturing location

What to Request

Pre-shipment samples for your own verification testing

Third-party lab reports (not just manufacturer CoA)

ISO 9001 or GMP certification documentation

Historical batch data showing consistency over time

5. Regulatory Compliance and Safety

Understanding the regulatory landscape isn't just about compliance - it's about knowing which markets your products can access.

Calcium disodium EDTA is approved as a food additive by both the FDA and the EU (E385). The EFSA has established an Acceptable Daily Intake (ADI) of 0-2.5 mg/kg body weight, while the FDA permits usage up to specific limits in designated food categories.

 

Safety Profile

EDTA-CaNa2 has a well-documented safety profile. Only 2-5% of orally consumed calcium disodium EDTA is absorbed in the gastrointestinal tract; the remainder is excreted unchanged. This low bioavailability contributes to its favorable safety margin in food applications. For detailed toxicological data, refer to the PubChem database entry.

Frequently Asked Questions

Is EDTA-CaNa2 the same as disodium EDTA?

No. While both are EDTA derivatives, calcium disodium EDTA (CAS 62-33-9) contains a chelated calcium ion, making it safer for applications where calcium depletion would be problematic. Disodium EDTA (CAS 139-33-3) can bind calcium from the body and is not interchangeable in pharmaceutical applications.

What is the minimum order quantity for bulk EDTA-CaNa2?

Most manufacturers, including MOSINTER, have a minimum order of 10 metric tons for bulk shipments. For smaller quantities, trial orders may be available upon request. Lead time is typically 7 days for standard specifications.

Is calcium disodium EDTA vegan and gluten-free?

Yes. EDTA-CaNa2 is synthesized from mineral sources (not animal-derived) and contains no gluten. It's suitable for vegan, vegetarian, and celiac-friendly formulations.

How should EDTA-CaNa2 be stored?

Store in a cool, dry place away from direct sunlight. While the compound is stable under normal conditions, excessive humidity can affect the hydration state. Properly stored, shelf life typically exceeds 24 months.

Can EDTA-CaNa2 be customized for specific applications?

Yes. Reputable manufacturers can adjust particle size, hydration form, and purity specifications based on your application requirements. Custom packaging options are also typically available.

 

Conclusion

Selecting the right EDTA-CaNa2 supplier directly impacts your formulation consistency, regulatory compliance, and ultimately, your end-product quality. With 21 years of manufacturing experience and a production capacity of 50,000 tons annually, MOSINTER delivers the batch-to-batch consistency that serious formulators demand.

Ready to discuss your EDTA-CaNa2 requirements?

Contact our technical team for specifications, samples, and competitive pricing.

WhatsApp: +86 18989305995

Email: info1@mosinterchem.com

Product Page: EDTA-CaNa2 Product Details

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Last Updated: January 2026